I virus trasmessi da zanzare e zecche sono una minaccia crescente
Approfondimenti
Blog Amal Fahmi – Organoidi
«Abbiamo dimostrato che il SARS-CoV-2 può infettare la placenta umana e che anche il virus del Nilo occidentale presenta caratteristiche di infezione placentare.»
Transmission du virus de Wesselsbron de la brebis à l’agneau : un flavivirus négligé en point de mire
La présente étude révèle un mode de transmission du virus, encore inconnu jusqu’ici de la brebis allaitante à ses agneaux et met en évidence un risque méconnu pour la santé publique et animale lié à la consommation de produits à base de lait cru. Elle montre également pour la première fois que les souches de ce virus présentent des tropismes hépatiques ou cérébraux différents.
Andrea Marti, Alexander Nater, Jenny Pego Magalhaes, Lea Almeida, Marta Lewandowska, Matthias Liniger, Nicolas Ruggli, Llorenç Grau-Roma, Fadi Alnaji, Marco Vignuzzi, Obdulio García-Nicolás, Artur Summerfield. Fitness adaptations of Japanese encephalitis virus in pigs following vector-free serial passaging. bioRxiv 2024 doi: https://doi.org/10.1101/2024.02.20.581151
Chiu YC, Baud D, Fahmi A, Zumkehr B, Vouga M, Pomar L, Musso D, Thuong BC, Alves MP, Stojanov M. Absence of Zika virus among pregnant women in Vietnam in 2008. Trop Dis Travel Med Vaccines. 2023 doi: 10.1186/s40794-023-00189-7.
Wang L, Moreira EA, Kempf G, Miyake Y, Oliveira Esteves BI, Fahmi A, Schaefer JV, Dreier B, Yamauchi Y, Alves MP, Plückthun A, Matthias P. Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways. Cell Rep. 2022 doi: 10.1016/j.celrep.2022.110736.
García-Nicolás O, Lewandowska M, Ricklin ME, Summerfield A. Monocyte-Derived Dendritic Cells as Model to Evaluate Species Tropism of Mosquito-Borne Flaviviruses. Front Cell Infect Microbiol. 2019 Jan 28;9:5. doi: 10.3389/fcimb.2019.00005.
Vielle NJ, García-Nicolás O, Oliveira Esteves BI, Brügger M, Summerfield A, Alves MP. The Human Upper Respiratory Tract Epithelium Is Susceptible to Flaviviruses. Front Microbiol. 2019. doi: 10.3389/fmicb.2019.00811.
Alves MP, Vielle NJ, Thiel V, Pfaender S. Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection. Viruses. 2018 doi: 10.3390/v10110593.
García-Nicolás O, Braun RO, Milona P, Lewandowska M, Dijkman R, Alves MP, Summerfield A. Targeting of the Nasal Mucosa by Japanese Encephalitis Virus for Non-Vector-Borne Transmission. J Virol. 2018 doi: 10.1128/JVI.01091-18.
García-Nicolás O, V'kovski P, Vielle NJ, Ebert N, Züst R, Portmann J, Stalder H, Gaschen V, Vieyres G, Stoffel M, Schweizer M, Summerfield A, Engler O, Pietschmann T, Todt D, Alves MP, Thiel V, Pfaender S. The Small-Compound Inhibitor K22 Displays Broad Antiviral Activity against Different Members of the Family Flaviviridae and Offers Potential as a Panviral Inhibitor. Antimicrob Agents Chemother. 2018 doi: 10.1128/AAC.01206-18.
Vielle NJ, Zumkehr B, García-Nicolás O, Blank F, Stojanov M, Musso D, Baud D, Summerfield A, Alves MP. Silent infection of human dendritic cells by African and Asian strains of Zika virus. Sci Rep. 2018 doi: 10.1038/s41598-018-23734-3.
Behrendt P, Perin P, Menzel N, Banda D, Pfaender S, Alves MP, Thiel V, Meuleman P, Colpitts CC, Schang LM, Vondran FWR, Anggakusuma, Manns MP, Steinmann E, Pietschmann T. Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry. Antiviral Res. 2017 doi:10.1016/j.antiviral.2017.09.006
García-Nicolás O, Ricklin ME, Liniger M, Vielle NJ, Python S, Souque P, Charneau P, Summerfield A. A Japanese Encephalitis Virus Vaccine Inducing Antibodies Strongly Enhancing In Vitro Infection Is Protective in Pigs. Viruses. 2017. doi: 10.3390/v9050124.
Lannes N, Neuhaus V, Scolari B, Kharoubi-Hess S, Walch M, Summerfield A, Filgueira L. Interactions of human microglia cells with Japanese encephalitis virus. Virol J. 2017 doi: 10.1186/s12985-016-0675-3.
Siddharta A, Pfaender S, Vielle NJ, Dijkman R, Friesland M, Becker B, Yang J, Engelmann M, Todt D, Windisch MP, Brill FH, Steinmann J, Steinmann J, Becker S, Alves MP, Pietschmann T, Eickmann M, Thiel V, Steinmann E. Virucidal Activity of World Health Organization-Recommended Formulations Against Enveloped Viruses, Including Zika, Ebola, and Emerging Coronaviruses. J Infect Dis. 2017. doi: 10.1093/infdis/jix046.
Baud D, Musso D, Vouga M, Alves MP, Vulliemoz N. Zika virus: A new threat to human reproduction. Am J Reprod Immunol. 2017 doi: 10.1111/aji.12614.
Pfaender S, Vielle NJ, Ebert N, Steinmann E, Alves MP, Thiel V. Inactivation of Zika virus in human breast milk by prolonged storage or pasteurization. Virus Res. 2017 doi: 10.1016/j.virusres.2016.11.025.
Ricklin ME, Garcìa-Nicolàs O, Brechbühl D, Python S, Zumkehr B, Posthaus H, Oevermann A, Summerfield A. Japanese encephalitis virus tropism in experimentally infected pigs. Vet Res. 2016 doi: 10.1186/s13567-016-0319-z. Japanese encephalitis virus tropism in experimentally infected pigs | Veterinary Research | Full Text (biomedcentral.com)
Ricklin ME, García-Nicolás O, Brechbühl D, Python S, Zumkehr B, Nougairede A, Charrel RN, Posthaus H, Oevermann A, Summerfield A. Vector-free transmission and persistence of Japanese encephalitis virus in pigs. Nat Commun. 2016 doi: 10.1038/ncomms10832. Vector-free transmission and persistence of Japanese encephalitis virus in pigs | Nature Communications
de Wispelaere M, Ricklin M, Souque P, Frenkiel MP, Paulous S, Garcìa-Nicolàs O, Summerfield A, Charneau P, Desprès P. A Lentiviral Vector Expressing Japanese Encephalitis Virus-like Particles Elicits Broad Neutralizing Antibody Response in Pigs. PLoS Negl Trop Dis. 2015 doi: 10.1371/journal.pntd.0004081.