Improved COVID-19 vector vaccine candidate
In response to the SARS-CoV-2 pandemic, numerous research projects have been launched to develop vaccines against this emerging pathogen. In a recent publication in the Nature portfolio journal «npj vaccines», scientists at the Institute of Virology and Immunology (IVI) and the University of Bern report on a Vesicular Stomatitis Virus (VSV)-vectored COVID-19 vaccine candidate. Their work shows that intramuscular immunization of mice with VSV-vectored COVID-19 vaccines is inducing strong antibody responses against the SARS-CoV-2 spike protein only if the vector has been complemented with the VSV glycoprotein G.
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